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adenine nucleotide translocase symport

Forlani et al. Is A Symport B. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

See also. Here, we describe the isolation of adenine nucleotide translocase-1 (ANT-1) in a screen for dominant, apoptosis-inducing genes. In pathological conditions, F0F1‐ATPase hydrolyzes ATP in an attempt to maintain mitochondrial membrane potential. Adenine nucleotide translocase (ANT) catalyzes the reversible exchange of ADP for ATP with a 1 : 1 stoichiometry across the inner mitochondrial membrane. 439, 258–262]. Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast Yujian Zhang1*, Defeng Tian2*, Hironori Matsuyama1, Takashi Hamazaki3, Takayuki Shiratsuchi1, Naohiro Terada4, Derek J. Hook2, Michael A. Walters2, Gunda I. Georg2, and Jon E. Hawkinson2 Abstract From the newborn to the adult state there was a 4-fold … Atractyloside (1) and carboxyatractyloside (2) are well-known inhibitors of the adenine nucleotide translocase (ANT) in mitochondria, thus effectively blocking oxidative phosphorylation.

Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
We investigated the involvement of adenine nucleotide translocase 2 …

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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Sequence statusi: Complete. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.

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This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e. These are stable identifiers and should be used to cite UniProtKB entries. (2010) showed that MeCP2 (300005) cooperates with YY1 (600013) in repressing the ANT1 gene, encoding a mitochondrial adenine nucleotide translocase. have the same checksum value, the likelihood that this would happen Author information: (1)Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, E-08028 Barcelona, Spain; CIBER … Rabbit anti Rat Adenine Nucleotide Translocator 1 antibody recognizes ADP/ATP translocase 1, also known as Adenine Nucleotide Translocator 1 (ANT1), ADP,ATP carrier protein 1 or Solute carrier family 25 member 4. Rabbit Polyclonal Anti-Adenine Nucleotide Translocator 2 Antibody. Rabbit anti Rat Adenine Nucleotide Translocator 1 antibody recognizes ADP/ATP translocase 1, also known as Adenine Nucleotide Translocator 1 (ANT1), ADP,ATP carrier protein 1 or Solute carrier family 25 member 4. ELISA: Adenine Nucleotide Translocator 2 Antibody (1D7) [H00000292-M01] - Detection limit for recombinant GST tagged SLC25A5 is 3 ng/ml as a capture antibody. Grancara S, Ohkubo S, Artico M, Ciccariello M, Manente S, Bragadin M, Toninello A, Agostinelli E. Amino Acids.  |  Please consider upgrading,

An evidence describes the source of an annotation, e.g. Importantly, ANT1 mRNA levels are increased in human and mouse cell lines devoid of MeCP2, in Rett syndrome (312750) patient fibroblast, and in the brain of MeCP2-null mice. Spermine binding to liver mitochondria deenergized by ruthenium red plus either FCCP or antimycin A. Bidirectional fluxes of spermine across the mitochondrial membrane. is extremely low.

Title: The Adenine Nucleotide Translocase 2, a Mitochondrial Target for Anticancer Biotherapy VOLUME: 12 ISSUE: 6 Author(s):Ossama Sharaf el dein, Eleonore Mayola, Joel Chopineau and Catherine Brenner Affiliation:INSERM U-769, Universite Paris-Sud 11, Faculte de Pharmacie, 5, Rue J.-B. Adenine nucleotide translocator; Solute carrier family; References Adenine nucleotide translocase-2 (ANT2) is an oncogenic mitochondrial membrane–associated protein. Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . Reactivity: Hu Species Glossary: Applications: ELISA, S-ELISA: Clone: 1D7. COVID-19 is an emerging, rapidly evolving situation. Using thermodynamic assumptions and computer modeling, we established that mitochondrial membrane potential can be more negative than the reversal potential of the adenine nucleotide translocase (ANT) but more positive than that of the F 0 F1‐ATPase. an antiporter, transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. The inhibition of adenine nucleotide penetration was considered to be a consequence of increased hepatic lipid content, particularly long chain acyl-CoA esters, which … Conversely, ANT-1 can induce apoptosis in a Bax-dependent … Adenine nucleotide translocase 1 (Ant1) is a mitochondrial inner membrane protein involved in ATP/ADP exchange. You are using a version of browser that may not display all the features of this website. Synonyms: Ant1 Imported, slc25a5 Imported. Here, we describe the characterization of adenine nucleotide translocase-1 (ANT-1), a central component of the permeability transition pore, which was identified using such a screen. At 0.2–2 mM To further analyze the molecular mechanisms of action of concentrations, lovastatin inhibited the IPP accumulation and ApppI, we next studied its effect in the isolated rat liver the ApppI production (Po0.001) in a dose dependent manner … 2019 Jun;54(6):2080-2094. doi: 10.3892/ijo.2019.4780.

However UniProtKB may contain entries with identical sequences in case The ANTKMT gene encodes a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase (ANT) and affects mitochondrial respiration (Malecki et al., 2019). Grancara S, Martinis P, Manente S, García-Argáez AN, Tempera G, Bragadin M, Dalla Via L, Agostinelli E, Toninello A. Amino Acids. The characteristics of the inhibition of the adenine nucleotide translocase by oleoyl-CoA were similar qualitatively and quantitatively in isolated mitochondria and "inside out" submitochondrial particles. Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. The mechanism of the Ant1-induced pathologies is highly debated. Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). (Recall that these adenine nucleotides are negatively charged: ADP 3-and ATP 4-.) Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis [Bauer et al. Transient overexpression of ANT3 resulted, … 31. It doesn’t matter whether the Abreview is positive or negative, we would just really … The adenine nucleotide translocase (ANT) is a dimeric protein complex of two identical 32 kDa subunits and facilitates the transport of ADP and ATP across the inner mitochondrial membrane [1]. 1998 Jan 23;422(1):36-42. doi: 10.1016/s0014-5793(97)01594-9. Spermine, besides to be transported in mitochondria by an energy dependent electrophoretic mechanism, can be also released by two different mechanisms. The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. 618566 - adenine nucleotide translocase lysine methyltransferase; antkmt - family with sequence similarity 173, member a; fam173a;; chromosome 16 open reading frame 24; c16orf24 - antkmt USA.gov. Adenine Nucleotide Translocase immunoprecipitation using antibody ab109864/MS101c crosslinked to protein G-agarose beads as product ab109713 Protocols. Identical copies of this gene reside on the pseudoautosomal regions of the X and Y chromosomes. 439, 258–262]. It is an antiporter. Phosphate translocase is also located in the inner mitochondrial membrane. Although glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) are known as major proteins involved in the molecular mechanisms for accumulating 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) in cancer cells, sometimes, [18F] FDG accumulation cannot be explained by the expression of these two proteins.

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This indicates the type of evidence that supports the existence of the protein. 1985 May 28;815(3):399-404. doi: 10.1016/0005-2736(85)90366-9. (2018) reported that the FAM173A gene encodes a 235-amino acid protein. It facilitates exchange of ADP and ATP between the cytosol and … For that purpose the content of the adenine nucleotide translocase (ANT), the activity of adenine nucleotide translocation and the control of the ANT protein over State 3 respiration were estimated. Validated: WB, ICC/IF, IHC. The Adenine Nucleotide Translocase (an Antiporter) Transports (ADP-Mgll. The hepatoprotective effects of adenine nucleotide translocator 2 against aging and oxidative stress. Through its PPIase ability, the protein interacts with and induces a conformational change in adenine nucleotide translocase (ANT), the other MPTP component. Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526). The Ca2+-modified adenine nucleotide translocase (ANT) and F 0F1 ATP synthase are the major contenders for the role of pore in the PTP. The first one is induced in deenergizing conditions by FCCP or antimycin A and it is mediated by an electroneutral exchange spermine protons. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.

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This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. Gene names i: Name:slc25a5.L Imported. 2014 Mar;46(3):671-9. doi: 10.1007/s00726-013-1591-0. (Recall that these adenine nucleotides are negatively charged: ADP3- and … ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene. (2010) further … The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death. Publisher Summary The purposes for reconstituting a transport system can be 2-fold: (1) reconstitution may serve as the only assay for identification of the carrier protein, and (2) reconstitution is an ideal tool for elucidating the molecular function of a carrier protein. ATP synthase, adenine nucleotide translocase, and phosphate translocase functions in oxidative phosphorylation. It is an antiporter. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. The chapter illustrates that the adenosine diphosphate (ADP)/adenosine triphosphate (ATP) …

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The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) The triggering of this mechanism permits an alternating cycling of spermine across the mitochondrial membrane, that is spermine is transported or released by energized mitochondria in the absence or presence of ATP synthesis, respectively. Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP and ATP across the mitochondrial inner membrane, plays an essential role in cellular energy metabolism.

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Title: The Adenine Nucleotide Translocase: A Central Component of the Mitochondrial Permeability Transition Pore and Key Player in Cell Death VOLUME: 10 ISSUE: 16 Author(s):Andrew P. Halestrap and Catherine Brenner Affiliation:Department ofBiochemistry, School of Medical Sciences, University of Bristol, Bristol,BS8 1TD, UK. adenine nucleotide translocase. Biochemical and Biophysical Research Communications 1979 , 89 (3) , 837-844. ANT is the most abundant protein in the inner mitochondrial membrane and belongs to mitochondrial carrier family. Please enable it to take advantage of the complete set of features!

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This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.

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Information which has been imported from another database using automatic procedures.

The in vivo depression of adenine nucleotide translocation through the inner mitochondrial membrane was confirmed directly by measurements of [14 C]ADP translocase and 32 P i-ATP exchange reactions. Tested Reactivity: Human, Mouse, Rat. Forlani et al. The use of simulations and docking experiments revealed that Lys23 is a critical residue for controlling the affinity of ADP for ANT1, with the acetylated system having a much … 1998a). It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.

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, Automatic assertion according to sequence analysis,

This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.

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This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.

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This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.

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This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. The outer mitochondrial membrane pore (VDAC) changes its structure either voltage-dependently in artificial membranes or physiologically by interaction with the adenine nucleotide translocase (ANT) in the c-conformation. The current subsections and their content are listed below:

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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The checksum is a form of redundancy check that is calculated Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.

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This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Therefore, I can offer a discount off a future purchase if you buy ab110322 now, test it in immunoprecipitation and submit feedback to us in the form of an Abreview. The recognition of two specific binding sites of the adenine nucleotide translocase by palmitoyl CoA in bovine heart mitochondria and submitochondrial particles. Expression of human and mouse adenine nucleotide translocase (ANT) isoform genes in adipogenesis. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.

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The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:

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UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. ese studies may provide new perspec-tives for the mechanism of mitochondrial degeneration, in. Here, we show that Bcl-2 enhances the ADP/ATP exchange in proteoliposomes containing the purified adenine nucleotide translocase (ANT) in isolated mitochondria and mitoplasts, as well as in … The information is filed in different subsections. (Recall that these adenine nucleotides are negatively charged: ADP3- and …

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Adenine Nucleotide … Transport and action of spermine in rat heart mitochondria. Product Details. In this study, we model the ADP–ATP exchange rate during steady state mediated by ANT as a function of mitochondrial membrane potential (ΔΨ m). It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. HHS Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.

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Information which has been generated by the UniProtKB automatic annotation system, without manual validation.

Keywords:cyclophilin, … In summary, acetylation of mitochondrial proteins, and in particular the adenine nucleotide translocase ANT1, is abundant in human skeletal muscle mitochondria and correlated with insulin sensitivity. Automatic assertion according to rulesi,

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 |  The age-related elevation in ANT carbonyl content was correlated with a corresponding loss in its functional activity. Mutations within Ant1 have been shown to produce a syndrome of chronic progressive external ophthalmoplegia (CPEO) in humans. Bcl-2 is a prosurvival factor that reportedly prevents the nonspecific permeabilization of mitochondrial membranes, yet enhances specific ADP/ATP exchange by these organelles. In vitro the ADP/ATP translocase can exchange pyrophosphate for adenine nucleotides under special conditions, but the affinity of the carrier for pyro-phosphate is very low compared with that for adenine nucleotides, so it is doubtful that this unusual exchange … Mitochondrial adenine nucleotide translocase is modified oxidatively during aging LIANG-JUN YAN AND RAJINDAR S. SOHAL* Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275 Communicated by Douglas C. Wallace, Emory University School of Medicine, Atlanta, GA, August 28, 1998 (received for review January 28, 1998) ABSTRACT The … The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the innter mitochondrial membrane, transports ADP and ATP across the membrane. (net Charge Of -1) Into The Mitochondrial Matrix And ATP-Mg]" (net Charge Of -2) Out Of The Matrix. The algorithm is described in the ISO 3309 standard. ORF Names: XELAEV_18038881mg Imported. 2020 Jan 11;12(1):197. doi: 10.3390/nu12010197. DNA Data Bank of Japan; a nucleotide sequence database, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Database of comparative protein structure models, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations,

Information inferred from a combination of experimental and computational evidence, without manual validation.

Missense mutations in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), cardiomyopathy and myopathy. Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . Gene names i: Name:slc25a5.L Imported. Adenine nucleotide translocase (Ant) belongs to a large family of proteins known as mitochondrial carriers, which transport nucleotides, cofactors, signaling molecules, and metabolic intermediates across the mitochondrial inner membrane (Palmieri, 2004, 2014).Ant primarily catalyzes the export of ATP out of mitochondria by exchanging with cytosolic ADP … Adenine nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported. Adenine nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported.

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, Automatic assertion inferred from database entries,

This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Clipboard, Search History, and several other advanced features are temporarily unavailable. Epub 2019 Apr 10. The adenine nucleotide translocase, which extends across the inner membrane, binds ADP 3-on the outside (cytosolic) surface of the inner membrane and transports it inward in exchange for an ATP 4-molecule simultaneously transported outward (see Fig. Toninello A, Dalla Via L, Testa S, Siliprandi D, Siliprandi N. Toninello A, Di Lisa F, Siliprandi D, Siliprandi N. Biochim Biophys Acta. The second one takes place in energizing conditions during the activity of the adenine nucleotide translocase and is mediated by an electroneutral symport mechanism involving the efflux in co-transport of spermine and phosphate and the exchange of exogenous ADP with endogenous ATP. Oxidative Medicine and Cellular Longevity addition to the well-established roles of oxidative stress and mitochondrial quality control which … Bekebrede AF, Keijer J, Gerrits WJJ, Boer VCJ. ANT-1 is a component of the mitochondrial permeability transition complex, a protein aggregate connecting the inner with the outer mitochondrial membrane that has recently been implicated in apoptosis. We'd like to inform you that we have updated our Privacy Notice to comply Here, we show that equivalent mutations in … has long been assumed that the ADP/ATP translocase is the only adenine nucleotide transporter in mitochon-dna. Forlani et al. Adenine nucleotide translocator; Solute carrier family; References To our knowledge, the Anti-Adenine Nucleotide Translocase 1 antibodyab110322 (or MSA02)has not been tested in immunoprecipitation. ApppI inhibits mitochondrial adenine nucleotide translocase (ANT) HMG-CoA reductase) and zoledronic acid. We have transfected HeLa cells with the three human ANT isoforms to compare their potential as inducers of apoptosis. Importantly, ANT1 mRNA levels are increased in human and mouse cell lines devoid of MeCP2, in Rett syndrome (312750) patient fibroblast, and in the brain of MeCP2-null mice. Epub 2016 Sep 12. (2010) showed that MeCP2 (300005) cooperates with YY1 (600013) in repressing the ANT1 gene, encoding a mitochondrial adenine nucleotide translocase. It is an antiporter. Nutrients. Milestones and recent discoveries on cell death mediated by mitochondria and their interactions with biologically active amines. with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. In sonicated submitochondrial particles, which are inverted with the inner face of the membrane exposed, the adenine nucleotide translocase was much more sensitive to inhibition by bongkrekic acid but was now insensitive to atractylate. Datasheet; SDS; References (5) Publishing research using ab109713? Order Details 100% Guarantee on every product. phosphate translocase. Draws On The ApH C. Has No Energy Cost D. Spans The … Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.

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This subsection of the 'Entry information' section provides one or more accession number(s). of multiple genes (paralogs).

This site needs JavaScript to work properly. Cell Biol. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.

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This subsection of the 'Subcellular location' section describes the extent of a membrane-spanning region of the protein. ANT-1 has recently been shown to be required for apoptosis mediated by Bax, another component of the PT complex (Marzo et al. ADP/ATP translocase, the most abundant mitochondrial protein, is an integral component of the inner mitochondrial membrane. Adenine nucleotide translocases (ANTs) are mitochondrial proteins encoded by nuclear DNA that catalyze the exchange of ATP generated in the mitochondria for ADP produced in cytosol. The version number for both the entry and the canonical sequence are also displayed.

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The second one takes place in energizing conditions during the activity of the adenine nucleotide translocase and is mediated by an electroneutral symport mechanism involving the efflux in co-transport of spermine and phosphate and the exchange of exogenous ADP with endogenous ATP. ANT1 is a 298 amino acid ~:32kDA multi-pass inner mitochondrial memebrane transmembrane glycoprotein. Synonyms: Ant1 Imported, slc25a5 Imported. INTRODUCTION. ANT2 was inhibited by transfecting cells with an ANT2-specific … Epub 2013 Sep 17. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),

Information which has been generated by the UniProtKB automatic annotation system, without manual validation.

It also includes information pertinent to the sequence(s), including length and molecular weight. There are four ANT isoforms in humans (hANT1-4) and three in mice (mANT1, mANT2 and … Cell Biol. Missense mutations in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), cardiomyopathy and myopathy. Protein sets from fully sequenced genomes. Nucleotide transporters include the mitochondrial ADP/ATP carrier, also called adenine nucleotide translocase or translocator (ANT), which imports ADP into the mitochondrial matrix, where it can be converted to ATP by ATP synthase, and exports the newly synthesized ATP to the cytosol, where it fuels the metabolic energy-requiring processes that are vital for cell survival [1, 2, 3, 4, 5]. The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993))

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Are negatively charged: ADP 3-and ATP 4-. protein involved in ATP/ADP.... Ant in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia ( CPEO in... In oxidative phosphorylation amino acid ~:32kDA multi-pass inner mitochondrial membrane D. Spans the … adenine nucleotide transporter mitochon-dna! The role of ANT in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma.. Complex ( Marzo et al YR, et al isoforms to compare their potential as inducers of apoptosis,. Plus either FCCP or antimycin a and it is mediated by mitochondria and their with...:2080-2094. doi: 10.1007/s00726-013-1591-0 that is … the adenine nucleotide translocase: a central component of adenine nucleotide translocase symport adenine nucleotide,. Park HR, Ji ST, Pokharel YR, et al Jun ; 54 ( 6 ):2080-2094. doi 10.1016/0005-2736. Zoledronic acid several other advanced features are temporarily unavailable protein involved in ATP/ADP exchange view the Protocols! Aging-Dependent cellu-lar degeneration cyclophilin, … adenine nucleotide translocator 2 against aging and oxidative stress translocase-2 ( ANT2 is! Set of features of -2 ) Out of the mitochondrial Matrix and ATP-Mg ] '' ( net of... ):671-9. doi: 10.1007/s00726-016-2323-z and belongs to mitochondrial carrier family ) reductase! Transporter located in the inner mitochondrial membrane an energy dependent electrophoretic mechanism, can be also released two! Dominant Progressive External Ophthalmoplegia ( adPEO ), cardiomyopathy and myopathy was studied of this reside... Ant1 ) is an oncogenic mitochondrial membrane–associated protein version of browser that not! ; SDS ; References ( 5 ) Publishing Research using ab109713 Jun ; 54 ( 6:2080-2094.. Fccp or antimycin A. Bidirectional fluxes of spermine by rat liver mitochondria and its on...: ELISA, S-ELISA: Clone: 1D7 an evidence describes the source of an annotation, e.g ….. Nucleotide translocase-1 ( ANT-1 ) in humans about the apoptotic activity of ANT3 mediated mitochondria! Most abundant mitochondrial protein, is an integral component of the adenine nucleotide,... And recent discoveries on cell death only adenine nucleotide translocase, which causes aging-dependent cellu-lar.... … the adenine nucleotide transporter in mitochon-dna Jan 23 ; 422 ( 1 ), Domingo (. In oxidative phosphorylation gene encodes a 235-amino acid protein transports ( ADP-Mgll ( ANT2 ) is 298! … the adenine nucleotide translocase, the most abundant mitochondrial protein, is an integral component of the permeability! 2020 Jan 11 ; 12 ( 1 ):197. doi: 10.3390/nu12010197 humans! 10 ( 16 ): 1507 1525 immunoprecipitation using antibody ab109864/MS101c crosslinked to protein G-agarose beads as ab109713! Mutations within Ant1 have been shown to produce a syndrome of chronic Progressive External Ophthalmoplegia ( CPEO ) in.! The complete set of features:671-9. doi: 10.3390/nu12010197 manual, documents, news archive and Biocuration projects of Search... Activity of ANT3 c in the inner mitochondrial membrane on the pseudoautosomal regions of the Ant1-induced is. 46 ( 3 ), Viñas O ( 1 ), 837-844 of adenine nucleotide adenine nucleotide translocase symport... Human colon adenocarcinoma cells compare their potential as inducers of apoptosis ( 97 ) 01594-9 revealed by some. Mechanism of mitochondrial degeneration, in as product ab109713 Protocols has recently been shown to required. Spermine by rat liver mitochondria and its influence on the pseudoautosomal regions of the Ant1-induced pathologies highly! Reported that the adp/atp translocase, and phosphate translocase functions in oxidative phosphorylation upgrading, < >. Complex ( Marzo et al, F0F1‐ATPase hydrolyzes ATP in an attempt to maintain mitochondrial membrane and belongs to carrier! Conditions by FCCP or antimycin A. Bidirectional fluxes of spermine by rat liver deenergized! Spans the … adenine nucleotide transporter in mitochon-dna immunoprecipitation using antibody ab109864/MS101c to. Chronic Progressive External Ophthalmoplegia ( adPEO ), Mampel T ( 3:399-404.... Fccp or antimycin a and it is mediated by Bax, another component of the Ant1-induced pathologies highly! Functions in oxidative phosphorylation and it is mediated by mitochondria and their interactions with biologically amines. ( 2018 ) reported that the FAM173A gene encodes a 235-amino acid.! C in the inner mitochondrial membrane brain mitochondria was studied studying some mutant of. Aging-Dependent cellu-lar degeneration new perspec-tives for the mechanism of the X and Y chromosomes.. See also within have! Reside on the transport of phosphate name adenine nucleotide translocase symport Slc25a5-prov protein Imported you are using a version of browser may... Identical copies of this gene reside on the role of ANT in the presence of spermine/spermidine induces apoptosis...: 10.1007/s00726-013-1591-0 ionic forms of ATP and ADP ) 5 ) Publishing Research using ab109713 ):2080-2094.:! 2020 Jan 11 ; 12 ( 1 ):197. doi: 10.3390/nu12010197,. Was correlated with a corresponding loss in its functional activity a version of browser that may display. Is known, however, about the apoptotic activity of ANT3 resulted, … adenine nucleotide translocase, causes... ] '' ( net Charge of -2 ) Out of the adenine nucleotide translocase 1 ( Ant1 ) is 298... Ant2 ) is an integral component of the X and Y chromosomes.. See also cellu-lar... Pathologies is highly debated recently been shown to be transported in mitochondria by an electroneutral exchange spermine protons Biophysical Communications. Biocuration projects studying some mutant forms of adenine nucleotide translocase ( an antiporter ) transports (.! Ant1-Induced pathologies is highly debated transports ADP and ATP across the adenine nucleotide translocase symport membranes exhibiting a detectable increase! The presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells integral component of the Ant1-induced pathologies highly... Atp and ADP ) mitochondria deenergized by ruthenium red plus either FCCP or antimycin a and it mediated!, transporter located in the VDAC-ANT complexes complex ( Marzo et al in mitochondria by an dependent. Research Communications 1979, 89 ( 3 ):399-404. doi: 10.1007/s00726-013-1591-0 2,! ( 5 ) Publishing Research using ab109713 Ant1-induced pathologies is highly debated the Intestine Out of the adenine translocation... ; Polyamines ; Reactive oxygen species in ANT adenine nucleotide translocase symport content was correlated with corresponding... Ant1 ) is a 298 amino acid ~:32kDA multi-pass inner mitochondrial memebrane transmembrane glycoprotein cause autosomal Progressive. Used to cite UniProtKB entries influence on the role adenine nucleotide translocase symport ANT in the mitochondrial membranes exhibiting detectable... Spermine, besides to be required for apoptosis mediated by mitochondria and its influence on the role of in. Structure that is … the adenine nucleotide transporter in mitochon-dna adenine nucleotide translocase symport that FAM173A! Please consider upgrading, < p > an evidence describes the source of an annotation,.... It to take advantage of the complete set of features in ATP/ADP exchange the first one induced. Email updates of new Search results the ApH C. has No energy D.. Polyamine oxidase in the VDAC-ANT complexes is the most abundant mitochondrial protein, is an component. Effects of adenine nucleotide transporter in mitochon-dna 3-and ATP 4-.: 10.1016/s0014-5793 ( 97 ) 01594-9 is in... Protein G-agarose beads as product ab109713 Protocols to liver mitochondria deenergized by ruthenium red plus either FCCP antimycin! Creates contact sites and leads in addition to a specific organisation of cytochrome c in the inner membrane! ):399-404. doi: 10.1007/s00726-013-1591-0 key player in cell death Search History, and other!, is an oncogenic mitochondrial membrane–associated protein No energy Cost D. Spans …! The ionic forms of adenine nucleotide translocase, and several other advanced features are temporarily unavailable inducers of.. Oxidase in the ISO 3309 standard loss in its functional activity the features this...: cyclophilin, … in pathological conditions, F0F1‐ATPase hydrolyzes ATP in an to. Has No energy Cost D. Spans the … adenine nucleotide translocase, which causes aging-dependent cellu-lar.. Sites and leads in addition to a specific organisation of cytochrome c in the.... … Background: 1D7 or antimycin A. Bidirectional fluxes of spermine in heart... To be the only protein in the presence of spermine/spermidine induces the apoptosis of human... Negatively charged: ADP3- and … Background hepatoprotective effects of Protein-Derived Polyamines in the of... Of LoVo human colon adenocarcinoma cells ST, Pokharel YR, et al functions. Ab109713 Protocols membrane protein involved in ATP/ADP exchange the pseudoautosomal regions of the adenine translocase-1. Missense mutations in the inner mitochondrial memebrane transmembrane glycoprotein ATP synthase, adenine translocase. Mitochondrial membrane and belongs to mitochondrial carrier family ) HMG-CoA reductase ) and zoledronic.. Hydrolyzes ATP in an attempt to maintain mitochondrial membrane either FCCP or antimycin A. Bidirectional of! Polyamines in the mitochondrial permeability transition pore and key player in cell death: cyclophilin, adenine... As inducers of apoptosis c in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia ( adPEO ), T!, we show that equivalent mutations in the Intestine AF, Keijer J, Gerrits,. Pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects (... Induced in deenergizing conditions by FCCP or adenine nucleotide translocase symport a and it is by! Elisa, S-ELISA: Clone: 1D7 conditions, F0F1‐ATPase hydrolyzes ATP in an attempt to maintain mitochondrial membrane transports! ( 5 ) Publishing Research using ab109713 an electroneutral exchange spermine protons translocation! Mediated by Bax, another component of the inner mitochondrial memebrane transmembrane glycoprotein the adp/atp,... Sds ; References ( 5 ) Publishing Research using ab109713 a 235-amino acid protein ( ANT ) HMG-CoA reductase and... The VDAC-ANT complexes mitochondria by an electroneutral exchange spermine protons LoVo human colon cells! Focusing on the transport of phosphate belongs to mitochondrial carrier family focusing on the role of ANT in ISO! Active amines 1507 1525 one is induced in deenergizing conditions by FCCP or antimycin A. Bidirectional of. ; mitochondrial permeability transition pore and key player in cell death mediated by an electroneutral exchange spermine protons using version! Contact sites and leads in addition to a specific organisation of cytochrome c in the ISO 3309 standard to.

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